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Sunday, April 29 — 3:15-5:15 PM Washington, DC Convention Center — Room 146A |
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| Chaired: |
Christopher Miller, Brandeis Univ. |
Ever since the first DNA sequences of cloned transport proteins became available, biophysicists have been trying to understand how these membrane-embedded macromolecules move hydrophilic solutes across membranes. This has traditionally been done - and done powerfully - by a combination of mutagenesis and close mechanistic analysis. In the past few years, new approaches have been introduced that take advantage of enhanced capabilities of protein biochemistry, leading to direct structural information, and of computational sophistication, which seeks to understand the energetics of these enormously complicated molecules.
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3:15 PM |
The new family of voltage-gated H+
channels. |
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3:45 PM |
Detection of electric fields in voltage-gated ion
channels. |
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4:15 PM |
Learning about channel gating from computations
combined with yeast screens. |
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4:45 PM |
Proton translocation coupled to proton gradients in anthrax
toxin
channel. |