the-aps.org>meetings>eb

Physiological Genomics: From Bench to Bedside
Sponsored by APS Physiological Genomics Group

During the past decade, there has been a great focus on linking biology to the genome. To translate raw genomic information into valuable information for use in the clinics, we must identify how genes function in living organisms. Several approaches have been developed to rapidly integrate complex physiological processes and interactions with the genome to aid in the understanding of complex diseases.  High-throughput phenotyping and genotyping, bioinformatics approaches, and publicly available data are allowing scientists to begin to link gene function with integrative physiology.  This symposium will present several integrative approaches available to translate gene function from the laboratory to the clinic.  This symposium has several purposes.  First, information can be gained from cellular and molecular studies rapidly but must be expanded to understand the impact on health and disease in a living system.  The first speaker will present recent studies aimed at understanding the role of hypoxia inducible factor 1 (HIF-1) both at the cellular level as well as in the whole animal and the resulting clinical implications.  The second speaker will describe how gene expression profiles can be used to dissect genetic and environmental factors impacting multigenic common diseases. The second purpose of this symposium is to introduce the audience to available resources to enable and support researchers interested in expanding their research to translate genomic information to the entire organism.  The final two speakers will introduce the audience to publicly available resources to promote and support researchers interested in heart, lung, blood and sleep disorders. The third speaker will review available mutant mouse models, the use of phenotype data to identify appropriate inbred models, and resources for complex trait analysis. The final speaker will describe how this information can be translated from the gene or cell level to a living system and used in the clinical setting.