the-aps.org>meetings>eb

Hypoxia and Cancer
Sponsored by APS Hypoxia Group
Oxidative Stress/Hypoxia Track

Human cancers are characterized by intratumoral hypoxia that results from dysregulated cell proliferation.  Physiological responses triggered by hypoxia impact on all critical aspects of cancer progression, including immortalization, transformation, differentiation, genetic instability, angiogenesis, metabolic adaptation, autocrine growth factor signaling,  invasion, metastasis, and resistance to therapy.  This symposium will focus on the cellular and molecular mechanisms by which cancer cells coopt adaptive physiological responses to hypoxia, particularly those that are mediated by the transcriptional activator hypoxia-inducible factor 1.