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Insulin Resistance and the Cardiometabolic Syndrome:  Adipose Tissue and Skeletal Muscle Factors
Sponsored by APS Endocrinology & Metabolism Section
Metabolic Abnormalities Track

Skeletal muscle constitutes the tissue that is primarily responsible for insulin stimulated glucose utilization.  Further, skeletal muscle insulin resistance is fundamental to the metabolic dysregulation associated with obesity and physical inactivity, and contributes to the development of type 2 diabetes mellitus and the cardiometabolic syndrome.  This symposium will discuss potential mediators of the insulin resistance that occurs with adipose tissue expansion and central distribution including intramuscular lipid accumulation, increased renin-angiotensin system and inflammatory cytokine pathways, and increased oxidative stress.  We will also explore strategies to maintain or improve skeletal muscle metabolic flexibility and insulin sensitivity including adequate physical activity, healthy weight and specific pharmacologic interventions.