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Sponsored by APS Cardiovascular Section Translational Physiology |
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Sunday, April 29 — 3:15-5:15 PM Washington, DC Convention Center — Room 147A |
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| Chaired: |
Steven P. Jones,
University of Louisville |
The field of cardioprotection has witnessed significant advances in terms of repair and regeneration of the infarcted heart within the last decade. However, several new areas of protection in native myocardium provide promise in attenuating post-ischemic injury. This symposium will evaluate several of such exciting avenues of cardioprotection. Dr. Baines will shed new light on the molecular identity of the mitochondrial permeability transition pore, a central element of cell fate. Dr. Murphy will present insights into GSK-3β, the potential “master regulator” of myocyte survival. The surprising role of iNOS as a protective moiety will be evaluated by Dr. Bhatnagar. Finally, Dr. Kitsis will address the molecular events associated with ARC and myocyte survival. A common theme among all of these presentations will be the involvement of the mitochondrion as a central element in cell survival or death. This session will span the gamut of experimental approaches from the intact animal, to intermolecular interactions and back, providing the audience with cutting-edge presentations on the newest areas of cardiac biology and mechanisms of post-ischemic myocardial injury.
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3:15 PM |
Molecular identity
of the mitochondrial permeability transition pore. |
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3:45 PM |
GSK-3β: a master
regulator of cardioprotection. |
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4:15 PM |
Inducible nitric
oxide synthase: cardioprotective facet of an inflammatory enzyme. |
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4:45 PM |
ARC, an inhibitor
of both the death receptor and mitochondrial apoptosis pathways. |