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Sponsored by Biomedical Engineering Society |
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Monday, April 30 — 8:00-10:00 AM Washington, DC Convention Center — Room 146B |
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| Chaired: |
Peter J. Butler, Penn State Univ. |
Endothelial cells convert mechanical stimuli from flowing blood into changes in cell signaling through a process called mechanotransduction. This symposium begins with reports on new investigations into vascular pathologies related to endothelial cell mechanotransduction followed by recent computational and experimental investigations into the fundamental molecular mechanisms by which endothelial cells sense mechanical forces. Such research elucidates the intricate and exquisite structures and processes by which endothelial cells transduce force into biological events affecting vascular health and disease.
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8:00 AM |
Introduction: Peter J. Butler, The Pennsylvania State
University |
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8:10 AM |
Endothelial phenotypes in vivo: hemodynamics and patho-susceptibility. |
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8:40 AM |
Implications of glycocalyx perturbation for endothelial
Mechanotransduction. |
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9:00 AM |
The functional significance of membrane rafts and caveolae in
localization of mechanosensory signaling complexes. |
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9:20 PM |
A mechanism for force-induced protein activation: vinculin
recruitment by talin. |
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9:40 AM |
On the transmission of fluid shear stress across the endothelial
glycocalyx and cytoskeletal reorganization. |