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| Sun. April 2—10:30 AM-12:30 PM |
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| Chaired: | Ora Weisz, Univ. of Pittsburgh James Casanova, Univ. of Virginia |
Epithelial polarity is maintained by the combination of polarized biosynthetic delivery, postendocytic sorting, and the presence of intercellular adhesive structures that function as diffusion barriers. Disruption of epithelial polarity can lead to aberrant ion transport, uncontrolled cell growth, and decreased resistance to viral and bacterial invasion. This session is designed to describe new advances in our understanding of how these pathways and structures are regulated, and will be of interest to researchers interested in the pathways by which epithelial polarity is regulated as well as those studying the physiology of epithelial organs.
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10:30 AM |
Regulation of cell polarity by Ral GTPases and the exocyst. |
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10:55 AM |
Protein
complexes and signal transduction mechanisms that control cell
polarity. |
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11:20 AM |
The role of Par-1 in
epithelial lumen formation. |
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11:45 AM |
Rab-mediated
sorting in polarized cells. |