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Physiology InFocus
From Molecules to Organisms: Approaches to Systems and Integrative
Physiology
The Lipid in Lipid Rafts: Lipids as Signaling Molecules
Mon. April 3—3:15-5:15 PM
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| Chaired: |
He-Ping Ma, Univ. of Alabama, Birmingham
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The old real estate saw that what's important is "Location, Location,
Location" also applies to cellular signaling. It has been clear for several
years that the local environment associated with lipid rafts determine
protein localization; but more recently, it has become clear that
over-and-above forming the structural basis for lipid rafts, the specialized
lipids in the rafts also are signaling molecules, themselves. This
symposium investigates the role of these lipids in regulating the formation
of lipid rafts and regulating the activity of proteins that are present in
rafts.
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3:15 PM |
Introduction: The lipids in lipid domains as signaling molecules.
Heping Ma, M.D. Univ. of Alabama, Birmingham
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3:25 PM |
Role of sphingomyelinase and ceramide in modulating lipid rafts.
Richard Kolesnick, Memorial Sloan-Kettering Cancer Ctr.
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3:50 PM |
Role of ceramide in regulating ion channels.
Alexander Carpinteiro, Univ. of Duisburg, Essen, Germany
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4:15 PM |
Visualization of lipid rafts by atomic force microscopy.
Robert M. Henderson, Univ. of Cambridge
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4:40 PM |
Lipid rafts and signal transduction.
Kai Simons, Max-Planck Institute, Germany
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5:05 PM |
General Discussion
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