Novel Partners and Mechanisms in Oxygen Sensing
Sponsored by the APS Hypoxia Group

It has long been known that acute and chronic episodes of hypoxia elicit short and long-term adaptive responses in many tissues of the body. However, only recently have we begun to appreciate fully the complex nature and interacting behaviour of signal transduction pathways which link environmental oxygen depletion to pertinent cellular responses in various parts of the body. Consequently, no coherent picture is available which maps the spatial and temporal progression of these adaptive responses during hypoxic regimens that mimic important cardiorespiratory diseases, such as pulmonary hypertension and congestive heart failure. For the first time, this symposium will provide a forum for public discussion of the latest data arising from the experimental interface between biochemistry and physiology. Together, these data are beginning to generate exciting new insights based on integration of novel protein partners and pathways, which are available for the generation of integrated adaptive responses hypoxic insult.