Physiological Effects of Ovarian Hormone Deficiency
Sponsored by the APS Endocrinology & Metabolism Section

Aging is associated with increased risk for heart disease, diabetes and physical disability. In women, the prevalence of these disorders increases dramatically after menopause. Because menopause is defined by the cessation of ovarian function, many investigators have hypothesized that the resulting ovarian hormone deficiency is of primary importance in promoting the development of chronic disease and disability. This hypothesis, however, is not well-founded. Our current understanding of the role that ovarian hormones play in regulating normal physiological function is limited and far less is known about the potential pathophysiological effects of ovarian hormone deficiency. This symposium will review our current knowledge of the effect of ovarian hormone availability on the regulation of regional adipose tissue cell metabolism, carbohydrate metabolism, cardiac structure/function and protein metabolism, with specific reference to how ovarian hormone deficiency may disrupt these systems and contribute to the development of chronic disease and disability.