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Endothelial cells convert mechanical stimuli from flowing blood into
changes in cell signaling through a process called mechanotransduction.
Advances in molecular-scale imaging of live cells and computational
methods in cell biology suggest that forces and cellular signaling are
highly correlated and localized. This symposium explores the relationship
between forces and molecular-scale signaling by drawing from investigators
who employ new computational and experimental tools to elucidate the
intricate and exquisite structures and processes by which endothelial
cells transduce force into biological events affecting vascular health and
disease
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10:30 AM |
Cell-specific solid modeling of living endothelial cells: multiphysics at
focal adhesions. |
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10:45 AM |
Discussion |
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10:50 AM |
Localized mechanosignaling mechanisms determine structural dynamics from
inside to outside the cell. |
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11:05 AM |
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11:10 AM |
Computational methods for probing the molecular basis of mechanotransduction. |
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11:25 AM |
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11:30 AM |
Mechanotransduction in endothelial cells mediated
by focal adhesion proteins. |
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11:45 AM |
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11:50 AM |
Mechanotransduction: understanding how cells sense mechanical signals
with novel microscopic and spectroscopic tools |
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12:05 PM |
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12:10 PM |
G protein and GPCR
activation by shear stress.
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12:25 PM |
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