77th APS President (2004-2005)
D. Neil Granger
Neil Granger is Boyd Professor and Head of the Department of Molecular and Cellular Physiology at the Louisiana State University (LSU) Health Sciences Center (LSUHSC) in Shreveport, LA. Born in Erath, LA, he attended the University of Southwestern Louisiana, earning the BS in microbiology in 1973. Granger received his doctorate in physiology and biophysics with Aubrey Taylor at the University of Mississippi Medical Center in 1977. His first faculty position was in the Department of Physiology at the University of South Alabama, where he was appointed Assistant Professor in 1977, Associate Professor in 1980, and Professor in 1983. In 1986, he assumed his present position as department head at LSUHSC, where he has also served at the Associate Dean for Research from 1993-2001.
Granger�s early research efforts were focused on regulation of fluid and solute exchange in the intestinal microcirculation. His later work centered on the contribution of reactive oxygen species to the microvascular dysfunction that results from reperfusion of ischemic tissues. He demonstrated a link between xanthine oxidase-derived reactive oxygen species, the adhesion of inflammatory cells to vascular endothelium, and subsequent injury to the vessel wall and parenchymal cells in postischemic tissues. This led to his work on defining the factors that regulate leukocyte-endothelial cells in the intact microcirculation in different models of acute and chronic inflammation. Granger�s current studies focus on mechanisms that underlie the exaggerated inflammatory and pro-thrombogenic responses in the microvasculature of postischemic tissues, and how risk factors for cardiovascular disease influence these responses. His research has been continuously funded by the National Heart Lung and Blood Institute since 1980, and he has been principal investigator of a Program Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases since 1991.
Granger has authored or co-authored over 400 research papers, many of which have appeared in the American Journal of Physiology. He currently serves on the editorial boards of the Heart & Circulation, GI & Liver, and Cell sections of the American Journal of Physiology, as well as Circulation Research, Microcirculation, Shock, Pathophysiology, Free Radical Biology & Medicine, and Lymphatic Research and Biology. In addition, he previously served on the editorial boards of NIPS, Gastroenterology, Digestive Diseases & Sciences, Journal of Critical Care, and Microvascular Research. Granger also served as Associate Editor of the American Journal of Physiology: GI & Liver (1985-1991) and as Editor-in-Chief of Microcirculation (1999-2003). He was a member of the Clinical Sciences-2 (1983-1986), Cardiovascular & Renal (1987-1991), and General Medicine-A2 (1992-1996) Study Sections and presently serves on the Gastrointestinal Mucosal Pathobiology Study Section. He also served on several peer review panels and policy committees for the American Heart Association, the Research Committee of the American Gastroenterological Association, and the Physiology Test Committee of the National Board of Medical Examiners (1988-1991). Granger served on the Council of the Microcirculatory Society (1982-1985) and as its President in 1991-1992. He was recently elected to serve (2003-2005) on the Council of the Association of Chairs of Departments of Physiology.
Granger became an active member of the APS in 1978. In addition to his editorial service for the American Journal of Physiology and NIPS, Granger has served on several APS committees, including the Membership Committee (1984-1985), the Animal Care and Experimentation Committee (1985-1988), and the Cardiovascular Section Steering (1983-1986), and Nominating (1991-1996) Committees. He was elected to serve on the APS Council from 1993-1996, and as Secretary/Treasurer of the Cardiovascular Section from 2002-2003. Granger represented the APS on the FASEB Research Conferences Committee (1987-1990) and served as Chair of that committee in 1989-1990. He also served as Chair of the APS Awards Committee from 1995-1997.
Granger has received several awards and honors for his research. These include the APS Bowditch Award, the Distinguished Research Award from the GI Section of the APS, the Landis Award from the Microcirculatory Society, the Laerdal Award from the Society for Critical Care Medicine, the McKenna Memorial Award from the Canadian Association of Gastroenterology, the Dolph Adams Award from the Society for Leukocyte Biology, and the Career of Distinction Award from the Oxygen Society. He was recently designated as a Highly Cited Investigator by the Institute for Scientific Information.