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74th APS President (2001-2002)
John E. Hall
(b. 1946)
John Hall is the Guyton Professor and Chairman of Physiology and
Biophysics and Director of the Center of Excellence in Cardiovascular-Renal
Research at the University of Mississippi Medical Center. Hall received his
doctorate in physiology with James Schwinghamer at Michigan State University
in 1974 and did postdoctoral training at the University of Mississippi
Medical Center with Arthur Guyton before joining the faculty in 1976. He was
promoted to full professor in 1982 and appointed as department Chair in
1989.
Hall’s major research interests include cardiovascular and renal
physiology, mechanisms of hypertension, the renin-angiotensin system,
obesity and insulin resistance, and modeling and computer simulation of the
cardiovascular-renal systems. His early work demonstrated the importance of
the direct intrarenal actions of angiotensin II (ANG II) in regulating renal
tubular sodium reabsorption, renal-pressure natriuresis, and long-term blood
pressure. His studies also found that ANG II, through its vasoconstrictor
effects on efferent arterioles, plays an important role in feedback control
of glomerular filtration. These studies provided the physiological basis for
understanding why renin-angiotensin system blockade may cause severe
decreases in glomerular filtration rate in patients with underperfused
kidneys (e.g., in renal artery stenosis), whereas renin-angiotensin system
blockade may be beneficial in lowering glomerular pressure and limiting
glomerular injury in patients with overperfused kidneys (e.g., in diabetes).
His laboratory also was the first to demonstrate that renal-pressure
natriuresis plays a crucial role in maintaining sodium balance in several
experimental models of hypertension and that increased arterial pressure
occurs as an essential compensation for impaired kidney function and an
inability to maintain sodium balance at normal arterial pressure. In recent
years, his research has helped to unravel the renal and neurohumoral
mechanisms that link obesity with hypertension and kidney disease. His
research has been continuously funded by the National Heart, Lung and Blood
Institute (NHLBI) since 1975, and he has been the principal investigator of
a Program Project Grant from NHLBI since 1988.
Hall has authored or co-authored over 390 publications and has written or
edited 11 books, including the Textbook of Medical Physiology, which he
co-authors with Arthur Guyton. He is Chief Editor of The American Journal of
Physiology: Regulatory, Integrative and Comparative Physiology and serves on
the editorial boards of several international journals. He is past Chairman
of the Council for High Blood Pressure Research, American Heart Association
(AHA); Chair of the Committee of Scientific Councils, AHA; and
President-Elect of the Inter-American Society of Hypertension. He also
serves on the executive committee of The American Society of Hypertension
and the Board of Directors of the AHA.
Hall has been an active member of APS since 1978. He is a member of the
Water and Electrolyte Homeostasis Section, the Renal Section, and a Fellow
of the Cardiovascular Section. He served as Chair, Treasurer, and Councillor
of the Water and Electrolyte Homeostasis Section, as a member of APS Council
in 1991, as Chair of SAC from 1997-2000, on the APS Strategic Planning
Committees in 1992 and 2000, on the Long-Range Planning Committee, on the
Task Force for Translational Research, on the Blue Ribbon Panel on APS
Programming, and on several other committees of APS. Hall’s awards include
the Richard Bright Award of the American Society of Hypertension, the Harry
Goldblatt Award of the American Heart Association, the Merck, Sharp and
Dohme International Research Award from the International Society of
Hypertension, the Lewis Dahl Award of the American Heart Association, the
Marion Young Scholar Award of the American Society of Hypertension, the
Ernest Starling Lectureship of the APS, The Burroughs Wellcome Fund Visiting
Professor in Basic Medical Sciences, the Special Research Achievement Award
of the AHA-Mississippi, an NIH Career Development Award, and the A.P.
Barnard and Billy S. Guyton Distinguished Professorships of The University
of Mississippi.
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