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77th APS President (2004-2005)
D. Neil Granger
(b. 1951)
Neil Granger is Boyd
Professor and Head of the Department of Molecular and Cellular Physiology
at the Louisiana State University (LSU) Health Sciences Center (LSUHSC) in
Shreveport, LA. Born in Erath, LA, he attended the University of
Southwestern Louisiana, earning the BS in microbiology in 1973. Granger
received his doctorate in physiology and biophysics with Aubrey Taylor at
the University of Mississippi Medical Center in 1977. His first faculty
position was in the Department of Physiology at the University of South
Alabama, where he was appointed Assistant Professor in 1977, Associate
Professor in 1980, and Professor in 1983. In 1986, he assumed his present
position as department head at LSUHSC, where he has also served at the
Associate Dean for Research from 1993-2001.
Granger’s early research efforts were focused on regulation
of fluid and solute exchange in the intestinal microcirculation. His later
work centered on the contribution of reactive oxygen species to the microvascular dysfunction that results from reperfusion of ischemic
tissues. He demonstrated a link between xanthine oxidase-derived reactive
oxygen species, the adhesion of inflammatory cells to vascular
endothelium, and subsequent injury to the vessel wall and parenchymal
cells in postischemic tissues. This led to his work on defining the
factors that regulate leukocyte-endothelial cells in the intact
microcirculation in different models of acute and chronic inflammation.
Granger’s current studies focus on mechanisms that underlie the
exaggerated inflammatory and pro-thrombogenic responses in the
microvasculature of postischemic tissues, and how risk factors for
cardiovascular disease influence these responses. His research has been
continuously funded by the National Heart Lung and Blood Institute since
1980, and he has been principal investigator of a Program Project Grant
from the National Institute of Diabetes and Digestive and Kidney Diseases
since 1991.
Granger has authored or co-authored over 400 research papers,
many of which have appeared in the American Journal of Physiology.
He currently serves on the editorial boards of the Heart & Circulation, GI
& Liver, and Cell sections of the American Journal of Physiology,
as well as Circulation Research, Microcirculation, Shock,
Pathophysiology, Free Radical Biology & Medicine, and
Lymphatic Research and Biology. In addition, he previously
served on the editorial boards of NIPS, Gastroenterology,
Digestive Diseases & Sciences, Journal of Critical Care, and
Microvascular Research. Granger also served as Associate Editor of the
American Journal of Physiology: GI & Liver (1985-1991) and as
Editor-in-Chief of Microcirculation (1999-2003). He was a member of
the Clinical Sciences-2 (1983-1986), Cardiovascular & Renal (1987-1991),
and General Medicine-A2 (1992-1996) Study Sections and presently serves on
the Gastrointestinal Mucosal Pathobiology Study Section. He also served on
several peer review panels and policy committees for the American Heart
Association, the Research Committee of the American Gastroenterological
Association, and the Physiology Test Committee of the National Board of
Medical Examiners (1988-1991). Granger served on the Council of the
Microcirculatory Society (1982-1985) and as its President in 1991-1992. He
was recently elected to serve (2003-2005) on the Council of the
Association of Chairs of Departments of Physiology.
Granger became an active member of the APS in 1978. In
addition to his editorial service for the American Journal of
Physiology and NIPS, Granger has served on several APS
committees, including the Membership Committee (1984-1985), the Animal
Care and Experimentation Committee (1985-1988), and the Cardiovascular
Section Steering (1983-1986), and Nominating (1991-1996) Committees. He
was elected to serve on the APS Council from 1993-1996, and as
Secretary/Treasurer of the Cardiovascular Section from 2002-2003. Granger
represented the APS on the FASEB Research Conferences Committee
(1987-1990) and served as Chair of that committee in 1989-1990. He also
served as Chair of the APS Awards Committee from 1995-1997.
Granger has received several awards and honors for his
research. These include the APS Bowditch Award, the Distinguished Research
Award from the GI Section of the APS, the Landis Award from the
Microcirculatory Society, the Laerdal Award from the Society for Critical
Care Medicine, the McKenna Memorial Award from the Canadian Association of
Gastroenterology, the Dolph Adams Award from the Society for Leukocyte
Biology, and the Career of Distinction Award from the Oxygen Society. He
was recently designated as a Highly Cited Investigator by the Institute
for Scientific Information.
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