Physiology in Medicine (PIM) is a series of articles published jointly by APS and Annals of Internal Medicine. It is printed in Annals and is provided free online to APS through the links below. The aim of this series is to provide practicing MD’s and/or researchers an up-to-date physiological understanding of disease with the proper application of new molecular models and tools. Articles published in this series are intended to provide a thoughtful and lucid linkage of science to the patient.

Submit an Article to Annals of Internal Medicine

Editor
D. J. Benos

Associate Editors
Edward Abraham
Peter Wagner

Annals of Internal Medicnie
H. Sox, Editor

Articles

• Jerry L. Spivak, MD. Narrative Review: Thrombocytosis, Polycythemia Vera, and JAK2 Mutations: The Phenotypic Mimicry of Chronic Myeloproliferation. Ann Intern Med 152: 300-306, 2010 (posted 3/4/10).
  
   

• Stewart J. Levine, MD, and Sally E. Wenzel, MD. Narrative Review: The Role of Th2 Immune Pathway Modulation in the Treatment of Severe Asthma and Its Phenotypes. Ann Intern Med 152: 232-237, 2010 (posted 2/16/10).
  
   

• Joel Rosenbloom, MD, PhD; Susan V. Castro, PhD; and Sergio A. Jimenez, MD. Narrative Review: Fibrotic Diseases: Cellular and Molecular Mechanisms and Novel Therapies. Ann Intern Med 152: 159-166, 2010 (posted 2/3/10).
  
   

• James R. Sowers, MD; Adam Whaley-Connell, DO; and Murray Epstein, MD. Narrative Review: The Emerging Clinical Implications of the Role of
  Aldosterone in the Metabolic Syndrome and Resistant Hypertension. Ann Intern Med 150: 776-783, 2009 (posted 6/1/09).
  
   

• Megan Greenlee, BS; Charles S. Wingo, MD; Alicia A. McDonough, PhD; Jang-Hyun Youn, PhD; and Bruce C. Kone, MD. Narrative Review: Evolving Concepts in Potassium Homeostasis and Hypokalemia. Ann Intern Med 150: 619-625, 2009 (posted 5/4/09).
  
   

• Marion L. Vetter, MD, RD; Serena Cardillo, MD; Michael R. Rickels, MD, MS; and Nayyar Iqbal, MD, MSCE. Narrative Review: Effect of Bariatric Surgery on Type 2 Diabetes Mellitus. Ann Intern Med 150: 94-103, 2009 (posted 1/22/09).
  
   

• Robert A. Brodsky, MD. Narrative Review: Paroxysmal Nocturnal Hemoglobinuria: The Physiology of Complement-Related Hemolytic Anemia. Ann Intern Med 148: 587-595, 2008 (posted 4/15/08).
  
   

• John H. Newman, MD; John A. Phillips III, MD; and James E. Loyd, MD. Narrative Review: The Enigma of Pulmonary Arterial Hypertension: New Insights from Genetic Studies. Ann Intern Med 148: 278-283, 2008 (posted 2/20/08).
  
   

• Joe T.R. Clarke, MD, PhD. Narrative Review: Fabry Disease. Ann Intern Med 146: 425-433, 2007 (posted 3/20/07).
  
   

• Eyal Reinstein, MD, PhD, and Aaron Ciechanover, MD, DSc. Narrative Review: Protein Degradation and Human Diseases: The Ubiquitin Connection. Ann Intern Med 145: 676-684, 2006 (posted 11/7/06).
  
   

• Amy Theos, MD, and Bruce R. Korf, MD, PhD. Pathophysiology of Neurofibromatosis Type 1. Ann Intern Med 144: 842-849, 2006. (posted 6/6/06)
  
   

• Jonathan M. McGavock, PhD; Ronald G. Victor, MD; Roger H. Unger, MD; and Lidia S. Szczepaniak, PhD. Adiposity of the Heart, Revisited. Ann Intern Med 144: 517-524, 2006 (posted 4/4/06).
  
   

• Jeff M. Sands, MD, and Daniel G. Bichet, MD. Nephrogenic Diabetes Insipidus. Ann Intern Med 144:186-194, 2006. (posted 2/13/06)
  
   

• Giorgos Bamias, MD; Mark R. Nyce, MD; Sarah A. De La Rue, PhD; and Fabio Cominelli, MD, PhD. New Concepts in the Pathophysiology of Inflammatory Bowel Disease. Ann Intern Med 143: 895-904, 2005. (published 12/20/05; posted 1/6/06)
  
   

• Timothy D. Starner, MD, and Paul B. McCray Jr., MD. Pathogenesis of Early Lung Disease in Cystic Fibrosis: A Window of Opportunity To Eradicate Bacteria. Ann Intern Med 143: 816-822, 2005. (published 12/6/05; posted 1/6/06)
  
   

• Hyon K. Choi, MD, DrPH; David B. Mount, MD; and Anthony M. Reginato, MD, PhD. Pathogenesis of Gout. Ann Intern Med 143: 499-516, 2005. (published 10/4/05; posted 1/6/06)
  
   

• Sean M. Caples, DO; Apoor S. Gami, MD; and Virend K. Somers, MD, PhD. Obstructive Sleep Apnea. Ann Intern Med 142: 187-197, 2005. (posted 2/1/05)
  
   

• John B. West, MD, PhD. The Physiologic Basis of High-Altitude Diseases. Ann Intern Med 141:789-800, 2004. (posted 11/16/04)
  
   

• Claude A. Piantadosi, MD, and David A. Schwartz, MD, MPH. The Acute Respiratory Distress Syndrome. Ann Intern Med 141: 460-470, 2004. (posted 9/22/04)
  
  

• Dennis J. Selkoe, MD. Alzheimer Disease: Mechanistic Understanding Predicts Novel Therapies. Ann Intern Med 140: 627-638, 2004. (posted 4/22/04)
  
   

• Clifford J. Woolf, MD. Pain: Moving from Symptom Control toward Mechanism-Specific Pharmacologic Management. Ann Intern Med 140: 441-451, 2004. (posted 3/22/04)
  
  
• Sergio A. Jimenez, MD, and Chris T. Derk, MD. Following the Molecular Pathways toward an Understanding of the Pathogenesis of Systemic Sclerosis. Ann Intern Med 140: 37-50, 2004. (posted 1/7/04)
  
  
• Suzanne Oparil, MD; M. Amin Zaman, MD; and David A. Calhoun, MD. Pathogenesis of Hypertension. Ann Intern Med 139: 761-776, 2003. (posted 11/4/03)
  
  
• Peter J. Barnes, DM, DSc, and Ian M. Adcock, PhD. How Do Corticosteroids Work in Asthma? Ann Intern Med 139: 359-370, 2003. (posted 9/3/03)
  
  
• J. Enrique Silva, MD. The Thermogenic Effect of Thyroid Hormone and Its Clinical Implications. Ann Intern Med 139: 205-213, 2003. (posted 8/21/03)
  
  
• Hershel Raff, PhD, and James W. Findling, MD. A Physiologic Approach to Diagnosis of the Cushing Syndrome. Ann Intern Med 138: 980-991, 2003. (posted 6/17/03)
  
  

• Daniel J. Brat, MD, PhD, and Timothy B. Mapstone, MD. Malignant Glioma Physiology: Cellular Response to Hypoxia and Its Role in Tumor Progression. Ann Intern Med 138: 659-669, 2003. (posted 5/8/03)
  

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