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Obesity Research Quick Links

Physiologists for many years have been at the forefront of obesity research and have uncovered much about its pathology. The following is a compilation of recent physiological research that explores obesity at pivotal developmental stages. 

Prenatal and Infancy

• “Postnatal intracerebroventricular exposure to neuropeptide Y causes weight loss in female adult rats” Am J Physiol Regul Integr Comp Physiol. 2003 Jun;284(6):R1560-6. Epub 2003 Feb 06 

• “Prenatal cytokine exposure results in obesity and gender-specific programming” Am J Physiol Endocrinol Metab. 2001 Aug;281(2):E326-34. 

• “Sedentary behavior during postnatal life is determined by the prenatal environment and exacerbated by postnatal hypercaloric nutrition” Am J Physiol Regul Integr Comp Physiol. 2003 Jul;285(1):R271-3.  

• “Fetal origins of hyperphagia, obesity, and hypertension and postnatal amplification by hypercaloric nutrition” Am J Physiol Endocrinol Metab. 2000 Jul;279(1):E83-7. 

• “Whole body insulin resistance in rat offspring of mothers consuming alcohol during pregnancy or lactation: comparing prenatal and postnatal exposure” J Appl Physiol. 2004 Jan;96(1):167-72. Epub 2003 Sep 12. 

• “Postnatal glucocorticoid exposure alters the adult phenotype” Am J Physiol Regul Integr Comp Physiol (March 4, 2004). 10.1152/ajpregu.00349.2003.   

Childhood

• “INS VNTR is a QTL for the insulin response to oral glucose in obese children” Physiol Genomics. 2004 Feb 13;16(3):309-13. 

• “Obesity by Choice: the powerful influence of nutrient availability on nutrient intake” Am J Physiol Regul Integr Comp Physiol. 2002 May;282(5):R1536-9. 

• “Relationships Among Adiponectin and Other Adipose Cytokines, Body Composition, and Fasting Insulin In Lower Socioeconomic Middle School Children” 

• “Low Intake of Minerals Associated with Growth and Reproduction in 110 Inner-City African American Mothers and their Daughters”

• “Effects of Candidate Genes on Growth Curves for Adiposity”

Adulthood

• “Waging war on physical inactivity: using modern molecular ammunition against an ancient enemy” J Appl Physiol. 2002 Jul;93(1):3-30. Review.

• “Tests of linkage and/or association of the LEPR gene polymorphisms with obesity phenotypes in Caucasian nuclear families” Physiol Genomics. 2004 Apr 13;17(2):101-6. Epub 2004 Feb 17. 

• “Leptin and the proinflammatory state associated with human obesity” J Clin Endocrinol Metab. 2004 Apr;89(4):1773-8. 

• “Metabolic adjustments with the development, treatment, and recurrence of obesity in obesity-prone rats” Am J Physiol Regul Integr Comp Physiol (March 25, 2004). 10.1152/ajpregu.00010.2004. 

• “Leptin prevents obesity induced by a high-fat diet after diet-induced weight loss in the marsupial S. crassicaudata” Am J Physiol Regul Integr Comp Physiol. 2004 Apr;286(4):R734-9. 

• “Obesity and hypertension: two epidemics or one?” Am J Physiol Regul Integr Comp Physiol 286: R803-R813, 2004; 10.1152/ajpregu.00707.2003.  

• “Total daily expenditure in free-living older African-Americans and Caucasians” Am J Physiol. 1998 Jan;274(1 Pt 1):E96-101. 

• “Feeding and temperature responses to intravenous leptin infusion are differential predictors of obesity in rats” Am J Physiol Regul Integr Comp Physiol. 2004 Apr;286(4):R756-63. 

• “Rising rates of adult disability, likely caused by obesity”

Elderly

• “Effect of aging on -adrenergically mediated thermogenesis in men” Am J Physiol. 1998 Jun;274(6 Pt 1):E1075-9.  

• “Contributions of total and regional fat mass to risk for cardiovascular disease in older women” Am J Physiol Endocrinol Metab. 2002 May;282(5):E1023-8. 

• “Physical Activity In The Elderly Ruled In Part By Genetics” 

• “High levels of myocardial antioxidant defense in aging nondiabetic normotensive Zucker obese rats” Am J Physiol Regul Integr Comp Physiol. 2004 Apr;286(4):R793-800. 

• “Obesity Hits Elderly Harder Than Younger Patients”

• “Obesity in the elderly: who should we be treating, and why, and how?” Curr Opin Clin Nutr Metab Care. 2004 Jan;7(1):3-9.

Society, Individuals and Obesity

• “Long-term, moderate exercise improves immune activity” 

• “Weight loss improves neurovascular and muscle metaboreflex control in obesity” Am J Physiol Heart Circ Physiol. 2003 Sep;285(3):H974-82. 

• “Correlates of Weight Loss Behaviors Among Low-Income African-American, Caucasian, and Latina Women” Obstet Gynecol. 2004 Feb;103(2):231-9. 

• “Program ENERGY: obesity and type-2 diabetes prevention through science education enrichment in the classroom” 

• “The Burden of Disease From Undernutrition and Overnutrition in Countries Undergoing Rapid Nutrition Transition: A View From Brazil” Am J Public Health. 2004 Mar;94(3):433-4. 

• “Childhood Overweight in a New York City WIC Population” Am J Public Health. 2004 Mar;94(3):458-62.