• Preemies’ Separation from Mom + Physical Stress May Increase Health Risks in Adulthood:  A new study suggests that physiological stress in premature infants combined with separation from their mothers may have lasting effects into adulthood. In clinical studies, these factors have been found to increase the risk of obesity and insulin resistance, leading to metabolic disorders such as metabolic syndrome and type 2 diabetes mellitus. The study is published ahead of print in the American Journal of Physiology—Regulatory, Integrative and Comparative Physiology.
  • Electrical Stimulation Improves Paralyzed Patients’ Function:  Nearly 282,000 people in the U.S. live with paralysis following a spinal cord injury (SCI). A review of more than 90 studies found that electrical stimulation may help restore function in those paralyzed after SCI. The article is published in Physiology.
  • New Generation Drugs May Hold Key to Alternative Erectile Dysfunction Treatment:  Close to 70 percent of men with erectile dysfunction (ED) respond to the ED drug sildenafil. However, only about 50 percent of men with diabetes—a population commonly affected by ED—achieve positive results with sildenafil. Researchers from the Smooth Muscle Research Centre at the Dundalk Institute of Technology, in Dundalk, Ireland, are studying two new drugs that may give men with diabetes—and others for whom conventional treatment is ineffective—new hope for treating ED. The article is published ahead of print in the American Journal of Physiology—Cell Physiology.
  • Young and Female: A Good Combination for Kidney Health?:  Young females may have the greatest level of protection against acute kidney injury (AKI) caused by the chemotherapy drug Cisplatin, commonly used to treat lung, ovarian, bladder and stomach cancer. Nearly a third of all people who are treated with Cisplatin develop AKI. The study—the first to investigate combined sex and age differences in the response to kidney injury—is published ahead of print in the American Journal of Physiology—Renal Physiology and was chosen as an APSselect article for September.
  • Turning Up the Heat Could Aid the Treatment of Cancer, Organ Transplant and Autoimmune Diseases:  Heat therapy may be a promising treatment in the fight against cancer, autoimmune problems and efforts to avoid organ rejection in transplant patients, according to researchers at the University of Kentucky. The research team exposed colorectal cancer cells and T-cells to temperatures lower and higher than normal body temperatures to observe the effects of temperature change on cellular energy production. They found that heat exposure can slow cancer cell growth and activate T-cells to fight infection. They will present their findings at the Physiological Bioenergetics: Mitochondria from Bench to Bedside conference in San Diego.
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